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2-Chloropropionyl chloride → 6-[p-(2-Chloropropionylamino)-phenyl]-4,5-dihydropyridaz-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chloropropionyl chloride | HCID 111019 | — |
| 反応物 | 6-(4-Aminophenyl)-4,5-dihydropyridazin-3(2H)-one | HCID 676750 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 6-[p-(2-Chloropropionylamino)-phenyl]-4,5-dihydropyridaz-3-one | HCID 20507198 | 93% |
反応手順
47.2 g (0.25 mole) of 6-(p-aminophenyl)-4,5-dihydropyridaz-3-one and 35.6 g (0.28 mole) of 2-chloropropionyl chloride in 250 ml of absolute benzene are refluxed for 2 hours. The product is filtered off at 10° C., washed first with benzene and then with water and dried under reduced pressure at 100° C. 64.8 g (93% of theory) of 6-[p-(2-chloropropionylamino)-phenyl]-4,5-dihydropyridaz-3-one are obtained as a beige solid which, after recrystallization from propanol, melts, with decomposition, at 243°-244° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04376771 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-f8980eeeaf50450da2a71f63c901e99e |
| 出典メモ | uspto-grants-1983_03 |