Hydrochloric Acid → alpha-Fluoro-alpha-isopropyl-4-chlorophenylacetic acid

HRID 354704ノート

反応式

HRID 354704 の反応式
[F:1][C:2]([C:11]1[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=1)([CH:8]([CH3:10])[CH3:9])[C:3]([O:5]CC)=[O:4].[OH-].[K+].Cl>CO.O>[F:1][C:2]([C:11]1[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=1)([CH:8]([CH3:10])[CH3:9])[C:3]([OH:5])=[O:4]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 13194588Ethyl alpha-fluoro-alpha-isopropyl-4-chlorophenylacetate

生成物 1

HCID 13194589alpha-Fluoro-alpha-isopropyl-4-chlorophenylacetic acid収率 87%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

A mixture of ethyl α-fluoro-α-isopropyl-4-chlorophenylacetate (1.42 g) and potassium hydroxide (0.35 g) in methanol (5 ml) was stirred at ambient temperature for 2.5 hours. The reaction mixture was acidified with hydrochloric acid, diluted with water and the aqueous mixture extracted with methylene chloride. The methylene chloride extract was dried over anhydrous sodium sulfate and the solvent removed by distillation under reduced pressure to give α-fluoro-α-isopropyl-4-chlorophenylacetic acid (1.10 g; 87%) m.p. 120° C.

後処理

  1. extractionthe aqueous mixture extracted with methylene chloride
  2. extractionThe methylene chloride extract
  3. dry with materialwas dried over anhydrous sodium sulfate
  4. customthe solvent removed by distillation under reduced pressure

出典と根拠

ORDレコード
ord-acc8cc1384f54075925fdc44ebb27e5f
出典データセット
uspto-grants-1983_03
特許番号
US04376784

反応ノート

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