Phenolate Sodium → 4-Hydroxybenzoic Acid

HRID 354722

反応式

HRID 354722 の反応式
[C:1]1([O-:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Na+].[C:9]([O-:18])(=[O:17])C1C(=CC=CC=1)O.[Na+]>>[CH:3]1[C:4]([C:9]([OH:18])=[O:17])=[CH:5][CH:6]=[C:1]([OH:7])[CH:2]=1

参加物

3

反応物 2

HCID 4445035Phenolate SodiumHCID 16760658Sodium Salicylate

生成物 1

HCID 1354-Hydroxybenzoic Acid

実験手順

In contrast to published information, it has been found that the degree of conversion of sodium phenolate to sodium salicylate is practically independent of the reaction temperature. At 165° C. and at 200° C., 85-88% conversion is easily obtained, but by-product formation is reduced as the temperature is increased. For instance, reaction at 140°-150° C. gives about 9% non-salicylic acids mostly 4-HBA in the crude product mixture whereas reaction at 190°-195° C. (at 5 bar co-pressure) gives less than 0.5% non-salicylic acids in the reaction product mixture.

後処理

  1. customAt 165° C. and at 200° C., 85-88% conversion is easily obtained
  2. temperatureis increased
  3. customFor instance, reaction at 140°-150° C.

出典と根拠

ORDレコード
ord-65514b3ffcfc48acbebe8fbcb4f6b5c5
出典データセット
uspto-grants-1983_03
特許番号
US04376867

関連ノート

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