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Hydrochloric Acid → 1-(2-Benzimidazolyl)-2-[(propyldithio)methyl]pyridinium chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Propyl mercaptan | HCID 7848 | — |
| 反応物 | Timoprazole | HCID 72171 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 1-(2-Benzimidazolyl)-2-[(propyldithio)methyl]pyridinium chloride | HCID 21295953 | — |
反応手順
2.6 g of 2-[(2-pyridylmethyl)sulphinyl]benzimidazole are dissolved in 30 ml of tetrahydrofuran and treated with 1.0 ml of n-propyl mercaptan. 10 ml of 3N hydrochloric acid are added at an internal temperature of 40°. The mixture is stirred at 40° for 5 minutes and then evaporated in vacuo. The residue is crystallized from ethanol/ether. There is obtained 1-(2-benzimidazolyl)-2-[(propyldithio)methyl]pyridinium chloride of melting point 144°-145°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04766133 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-fa30a22ce0ca4274b65e81863b1b0172 |
| 出典メモ | uspto-grants-1988_08 |