Triethylamine → 5-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

HRID 354787

反応式

HRID 354787 の反応式
Cl[CH2:2][CH2:3][C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[CH:21][C:7]1=2)=[O:5].C(N(CC)CC)C>C(O)C>[C:4]([N:6]1[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=2[C:10](=[O:17])[NH:9][C:8]2[CH:18]=[CH:19][CH:20]=[CH:21][C:7]1=2)(=[O:5])[CH:3]=[CH2:2]

参加物

4

反応物 2

HCID 8471TriethylamineHCID 128346825-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

生成物 1

HCID 128347105-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5.0 gm (0.017 mol) of 5-(3-chloro-propionyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2.0 gm (0.02 mol) of triethylamine were refluxed in 250 ml of ethanol for 30 minutes. Subsequently, the reaction mixture was evaporated in vacuo, and the residue was stirred with water. After suction-filtering and drying, 5-acryloyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one was obtained with a quantitative yield. Recrystallization from ethanol.

後処理

  1. customSubsequently, the reaction mixture was evaporated in vacuo
  2. filtrationAfter suction-filtering
  3. customdrying

出典と根拠

ORDレコード
ord-a53088ad3e5d4f2db3eefbeecda9ce35
出典データセット
uspto-grants-1983_03
特許番号
US04377576

関連ノート

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