Isoamyl Alcohol → 2-(4-Benzylpiperidin-1-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride

HRID 354813ノート

反応式

HRID 354813 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[N:5]=[C:4]([Cl:16])[N:3]=1.[CH2:17]([CH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(O)CC(C)C>C(OCC)C>[ClH:16].[CH2:17]([CH:24]1[CH2:29][CH2:28][N:27]([C:4]2[N:3]=[C:2]([NH2:1])[C:11]3[C:6](=[C:7]([O:14][CH3:15])[C:8]([O:12][CH3:13])=[CH:9][CH:10]=3)[N:5]=2)[CH2:26][CH2:25]1)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 31260Isoamyl AlcoholHCID 317384-BenzylpiperidineHCID 129200082-Chloro-4-amino-7,8-dimethoxyquinazoline

生成物 1

HCID 205064012-(4-Benzylpiperidin-1-yl)-4-amino-7,8-dimethoxyquinazoline hydrochloride収率 60%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

4-Amino-2-chloro-7,8-dimethoxyquinazoline (2.40 g., 10 mmole), 4-benzylpiperidine (1.93 g., 11 mmole) and 50 ml. of isoamyl alcohol were heated at reflux under a nitrogen atmosphere for two hours and cooled to room temperature. Diethyl ether (50 ml.) was added and the mixture allowed to stand in the refrigerator for two days. The precipitated solid was collected by filtration and recrystallized from ethanol/diethyl ether to afford 2.50 g. (60%) of the title compound, M.P. 216°-217° C.

後処理

  1. temperatureat reflux under a nitrogen atmosphere for two hours
  2. filtrationThe precipitated solid was collected by filtration
  3. customrecrystallized from ethanol/diethyl ether
  4. customto afford 2.50 g

出典と根拠

ORDレコード
ord-738b498cf9a84bc89a565bd2423aa57a
出典データセット
uspto-grants-1983_03
特許番号
US04377581

反応ノート

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