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2-Chromanecarbonyl chloride → 2-[4-(2,3-Dihydro-4H-benzopyran-2-carbonyl)-piperazin-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chromanecarbonyl chloride | HCID 2794583 | — |
| 反応物 | HCID 20506419 | HCID 20506419 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-[4-(2,3-Dihydro-4H-benzopyran-2-carbonyl)-piperazin-1-yl]-4-amino-6-chloro-7-methoxyquinazoline hydrochloride | HCID 20506434 | — |
反応手順
To 0.10 mole of 2-(piperazin-1-yl)-4-amino-6-chloro-7-methoxyquinazoline in 300 ml. of methanol is added with vigorous stirring, 0.10 mole of 2,3-dihydro-4H-benzopyran-2-carboxylic acid chloride. After the addition is complete, the mixture is stirred for three hours at room temperature and the precipitated title compound is collected by filtration.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04377581 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-08e69cb881ff405182ce571a94b7fedf |
| 出典メモ | uspto-grants-1983_03 |