4-Aminoquinazoline → Dimethyl [(4-quinazolinylamino)methylene]propanedioate

HRID 354866

反応式

HRID 354866 の反応式
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][N:3]=1.CO[CH:14]=[C:15]([C:20]([O:22][CH3:23])=[O:21])[C:16]([O:18][CH3:19])=[O:17]>CN(C)C=O>[N:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([NH:1][CH:14]=[C:15]([C:20]([O:22][CH3:23])=[O:21])[C:16]([O:18][CH3:19])=[O:17])=[N:3][CH:4]=1

参加物

4

反応物 2

HCID 847594-AminoquinazolineHCID 90770Dimethyl methoxymethylenemalonate

生成物 1

HCID 86738820Dimethyl [(4-quinazolinylamino)methylene]propanedioate収率 92.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
150 °C

実験手順

A mixture of 4-aminoquinazoline (7.27 g) and dimethyl methoxymethylenepropanedioate (9.6 g) in N,N-dimethylformamide (35 ml) was stirred for 2 hours at 150° C. The reaction mixture was cooled to ambient temperature and poured into ice-water to give crystals, which were separated by filtration, washed with water and dried to ambient temperature to give a mixture (13.3 g) of dimethyl [(4-quinazolinylamino)methylene]propanedioate and methyl 4-oxo-4H-pyrimido[1,2-c]quinazoline-3-carboxylate.

後処理

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. customto give crystals, which
  3. customwere separated by filtration
  4. washwashed with water
  5. customdried to ambient temperature

出典と根拠

ORDレコード
ord-d4a58274e2c24f558519a627f1b5b1e5
出典データセット
uspto-grants-1983_03
特許番号
US04377580

関連ノート

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