関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Dimethyl methoxymethylenemalonate | HCID 90770 | — |
| 反応物 | 4-Amino-6-(3,3-dimethylbutyramido)quinazoline | HCID 13060460 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Dimethyl[{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate | HCID 13060506 | 82.7% |
反応手順
A mixture of 4-amino-6-(3,3-dimethylbutyramido)quinazoline (8.5 g), dimethyl methoxymethylenepropanedioate (12.75 g) and N,N-dimethylformamide (34 g) was stirred for an hour at 100° C. After cooling to ambient temperature, to the resultant mixture was added water to give precipitates, which were separated by filtration, washed with water and dried to give crystalline dimethyl [{6-(3,3-dimethylbutyramido)-4-quinazolinylamino}methylene]propanedioate (10.9 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04377580 |
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| 出典データセット | uspto-grants-1983_03 |
|---|
| ORD ID | ord-6f04d01d001e42d49a57e812aa48595c |
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| 出典メモ | uspto-grants-1983_03 |
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