反応式
[Br:1][CH:2]([CH3:12])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)=[O:4].[CH2:13]([C:20]1[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.CO>C(O)C>[Br-:1].[CH2:13]([C:20]1[CH:25]=[CH:24][N+:23]([CH:2]([C:3]([C:5]2[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=2)=[O:4])[CH3:12])=[CH:22][CH:21]=1)[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1参加物
5
実験手順
In the condensation step, the condensation reaction between 2-bromo-4'-hydroxypropiophenone and 4-benzylpyridine is smoothly promoted in the presence of methanol and/or ethanol whereby a ketone compound of the general formula: ##STR2## i.e. 4-benzyl-1-[1-(4-hydroxyphenylcarbonyl)ethyl]-pyridinium bromide is formed in the reaction mixture. The time and the temperature adopted for the condensation reaction are usually 3-6 hours and 60°-90° C., respectively. The reaction mixture thus obtained is directly subjected as such, without isolating the above condensation product, to the catalytic reduction in the subsequent step. In this case, an additional amount of methanol and/or ethanol may be supplied to the reaction mixture.
後処理
- customIn the condensation step
出典と根拠
- ORDレコード
- ord-22270f1a9cbb471da6a4bb893786a63d
- 出典データセット
- uspto-grants-1983_03
- 特許番号
- US04377691
関連ノート
読み込み中…