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Hydrochloric Acid → HCID 57177388、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 1,2,3,6-Tetrahydropyridine | HCID 12750 | — |
| 反応物 | Benzoic acid, 2-chloro-5-(chlorosulfonyl)- | HCID 67306 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 57177388 | HCID 57177388 | — |
反応手順
2-Chloro-5-chlorosulfonylbenzoic acid (25.5 g.) is added in small portions over a 5 minute period with cooling to a solution of 1,2,5,6-tetrahydropyridine (25.0 g.) in 200 ml. of water. After stirring at room temperature for a half hour, the reaction mixture is acidified with concentrated hydrochloric acid. The crystalline precipitate is filtered off and dissolved in 75 ml. of methylene chloride and 10 ml. of ether. After concentration to 50 ml., hexane is added to turbidity, affording crystals, m.p. 180°-182° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04377521 |
| 出典データセット | uspto-grants-1983_03 |
| ORD ID | ord-e1cc92d96e384ebd9f14ddf9ddf568af |
| 出典メモ | uspto-grants-1983_03 |