1,2-Dimethylindole → 5-(2-ethyl-5-methyl-3-indolyl)-5-(1-benzyl-5-fluoro-3-indolyl)-3,4-dichloro-2(5H)-furanone

HRID 355159

反応式

HRID 355159 の反応式
[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12](=O)[C:13]([Cl:19])=[C:14]([Cl:18])[C:15]([OH:17])=[O:16])=[CH:9][C:8]([CH3:21])=[CH:7][CH:6]=2)[CH3:2].[CH2:22]([N:29]1[C:37]2[C:32](=[CH:33][C:34]([F:38])=[CH:35][CH:36]=2)[CH:31]=[CH:30]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.CN1C2C(=CC=CC=2)C=C1C>>[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]1([C:31]3[C:32]4[C:37](=[CH:36][CH:35]=[C:34]([F:38])[CH:33]=4)[N:29]([CH2:22][C:23]4[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=4)[CH:30]=3)[O:16][C:15](=[O:17])[C:14]([Cl:18])=[C:13]1[Cl:19])=[CH:9][C:8]([CH3:21])=[CH:7][CH:6]=2)[CH3:2]

参加物

4

反応物 3

HCID 134081,2-DimethylindoleHCID 197966391-Benzyl-5-fluoro-1H-indoleHCID 537385614-(2-Ethyl-5-methyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid

生成物 1

HCID 204427195-(2-ethyl-5-methyl-3-indolyl)-5-(1-benzyl-5-fluoro-3-indolyl)-3,4-dichloro-2(5H)-furanone

実験手順

Following a procedure similar to that described above in part B of this example except that 4-(2-ethyl-5-methyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid is used in place of 4-(1,2-dimethyl-3-indolyl)-2,3-dichloro-4-oxo-2-butenoic acid and 1-benzyl-5-fluoroindole is substituted for 1,2-dimethylindole, there is obtained 5-(2-ethyl-5-methyl-3-indolyl)-5-(1-benzyl-5-fluoro-3-indolyl)-3,4-dichloro-2(5H)-furanone (Formula V: R=R3 =H; R1 =CH3CH2 ; R2 =C6H5CH2 ; Y=5-CH3 ; Y1 =5-F).

出典と根拠

ORDレコード
ord-a7e41fd7b0e044549a3235b739c58aa1
出典データセット
uspto-grants-1983_03
特許番号
US04377698

関連ノート

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