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2-Amino-5-methylpyridine → 2-[4-(Ethoxycarbonyl)phenyl]-6-methyl-imidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-5-methylpyridine | HCID 15348 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Ethyl 4-(2-bromoacetyl)benzoate | HCID 11966043 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-[4-(Ethoxycarbonyl)phenyl]-6-methyl-imidazo[1,2-a]pyridine | HCID 13691327 | — |
反応手順
67 g (0.62 mole) of 2-amino-5-methylpyridine, 86 g (1.02 mole) of sodium bicarbonate and 143 g (0.527 mole) of ethyl 4-(2-bromoacetyl)benzoate are introduced into 1 l of ethanol. The mixture is brought to reflux for 3 hours and left standing for 19 hours, and the solid formed is recovered by filtration, washed copiously with water and dried. It is recrystallized in a dichloromethane/methanol mixture. M.p. 228°-230° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04767755 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-96d705b1b3cb490481bc6f1bde1cbad9 |
| 出典メモ | uspto-grants-1988_08 |