2-Amino-5-methylpyridine → 6-Methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine

HRID 35520

反応式

HRID 35520 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)=O.[NH2:14][C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[CH:17][N:16]=1.C(=O)(O)[O-].[Na+]>C(O)C>[CH3:21][C:18]1[CH:19]=[CH:20][C:15]2[N:16]([CH:2]=[C:3]([C:5]3[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=3)[N:14]=2)[CH:17]=1

参加物

5

反応物 3

HCID 153482-Amino-5-methylpyridineHCID 668402-Bromo-4'-nitroacetophenoneHCID 516892Sodium Bicarbonate

生成物 1

HCID 7499176-Methyl-2-(4-nitrophenyl)imidazo[1,2-a]pyridine

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

59.5 g (0.2 mole) of 1-bromo-2-(4-nitrophenyl)-2-ethanone, 21.6 g (0.2 mole) of 2-amino-5-methylpyridine and 34 g of sodium bicarbonate are reacted in 200 ml of 95% strength ethanol. Stirring and refluxing are maintained for 3 hours, and the reaction mixture is then cooled and the ethanol evaporated off under reduced pressure. The evaporation residue is stirred in 700 ml of water at 70° C. for 3 hours, and the insoluble material is then filtered off, washed with 50 ml of ethanol and then ether and dried. M.p. 237°-239° C.

後処理

  1. temperaturerefluxing
  2. temperatureare maintained for 3 hours
  3. temperaturethe reaction mixture is then cooled
  4. customthe ethanol evaporated off under reduced pressure
  5. stirringThe evaporation residue is stirred in 700 ml of water at 70° C. for 3 hours
  6. filtrationthe insoluble material is then filtered off
  7. washwashed with 50 ml of ethanol
  8. dry with materialether and dried

出典と根拠

ORDレコード
ord-0a808d8832164fd696ba306bfcf7bb18
出典データセット
uspto-grants-1988_08
特許番号
US04767755

関連ノート

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