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Water → 2-(3-Methoxybenzylthio)nicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 3-Methoxybenzyl chloride | HCID 69994 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 反応物 | HCID 178524460 | HCID 178524460 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-(3-Methoxybenzylthio)nicotinic acid | HCID 859340 | — |
反応手順
A suspension of 4.65 g (0.03 mole) of 2-mercaptonicotinic acid in 100 ml of methanol was cooled in ice as 3.24 g (0.06 mole) of sodium methoxide was added. The resulting solution was left at ice - temperature as 4.68 g (0.03 mole) of 3-methoxybenzyl chloride was added over 5 minutes. The reaction mixture was stirred for 14 hours and the reaction set solid. The addition of 50 ml of water caused solution and an excess of acetic acid precipitated 7.55 g (92% of theory) of 2-(3-methoxybenzylthio)nicotinic acid. Recrystallization was effected from ethyl acetate; m.p. 156-157° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04767766 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-6f633874bdd242acb222fcad7b159dc6 |
| 出典メモ | uspto-grants-1988_08 |