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Hydrochloric Acid → 1,5-Diphenylpyrazolidin-3-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Phenylhydrazine | HCID 7516 | — |
| 反応物 | Ethyl 3-phenylprop-2-enoate | HCID 7649 | — |
| 反応物 | Sodium Methoxide | HCID 10942334 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 1,5-Diphenylpyrazolidin-3-one | HCID 3695373 | — |
反応手順
One hundred and seventy-six (176) grams of ethyl cinnamate, 108 g of phenylhydrazine, 200 ml of a 28% methanol solution containing sodium methoxide, and 400 ml of acetonitrile were mixed and refluxed with heating in the nitrogen atmosphere for 1 hour. The reaction solution was poured into 2 liters of water and 100 ml of concentrated hydrochloric acid was added, thereby precipitation was formed. This was filtered off and recrystallized with acetonitrile to obtain 180 g of 1-phenyl-5-phenylpyrazolidin-3-one (A) as white crystals. ##STR10## Synthesis of Compound (B)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05830627 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-6d1fd1ca067943bf99054fafecf12191 |
| 出典メモ | uspto-grants-1998_11 |