化工社化工社 化学情報印刷レポート · 研究参考用
p-Toluenesulfonic acid monohydrate → 4-Methoxycarbonyl-4-phenylpiperidine p-toluenesulfonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid monohydrate | HCID 521998 | — |
| 反応物 | 4-Piperidinecarboxylic acid, 4-phenyl-, 4-methylbenzenesulfonate (1:1) | HCID 2723657 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 4-Methoxycarbonyl-4-phenylpiperidine p-toluenesulfonate | HCID 21699518 | 453.8% |
反応手順
1 g of p-toluenesulphonic acid monohydrate is added to a solution of 10 g of 4-carboxy-4-phenylpiperidine p-toluenesulphonate in 300 ml of MeOH, and the reaction mixture is heated to reflux for 3 days. It is concentrated under vacuum, the residue is taken up in acetone and ether is added until precipitation takes place. After draining of the precipitate formed, 9.34 g of the expected product are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05830906 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-1f039885973f400ab1f5df807ddab499 |
| 出典メモ | uspto-grants-1998_11 |