Diethyl Ether → 4-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide

HRID 355463ノート

反応式

HRID 355463 の反応式
[Br:1]Br.Cl.[C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)(=[O:6])[CH3:5].CCOCC>C(Cl)Cl>[BrH:1].[Br:1][CH2:5][C:4]([C:7]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]1)=[O:6]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 24408BromineHCID 27237674-Acetyl-4-phenylpiperidine hydrochloride

生成物 1

HCID 227417564-(2-Bromoacetyl)-4-phenylpiperidine hydrobromide収率 196.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

8 g of bromine are added rapidly at RT to a suspension of 11.98 g of 4-acetyl-4-phenylpiperidine hydrochloride in 200 ml of DCM, and the reaction mixture is left stirring overnight at RT. It is diluted by adding 200 ml of ether, and the precipitate formed is drained and washed with ether. 17.88 g of the expected product are obtained after drying under vacuum.

後処理

  1. waitthe reaction mixture is left
  2. additionIt is diluted
  3. customthe precipitate formed
  4. washwashed with ether

出典と根拠

ORDレコード
ord-7e9dc4906751498b9c07a52496974797
出典データセット
uspto-grants-1998_11
特許番号
US05830906

反応ノート

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