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Hexahydro-1H-azepine-1-ethanol → 2-Homopiperidinylethyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hexahydro-1H-azepine-1-ethanol | HCID 88615 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | Methyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate | HCID 21294482 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-Homopiperidinylethyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate | HCID 57191089 | 60% |
反応手順
By treating 17.31 g of methyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate (II, R=CF3, R"=CH3), 10.5 g of 1-(2-hydroxyethyl)homopiperidine in 130 ml of toluene and in the presence of sodium as described in Example 1, 20.6 g of a crude material are isolated. The recrystallization in diisopropyl ether enables to isolate 13.7 g (yield: 60%) of a whitish solid with m.p. 72°-75° C. and elemental analysis C, H, N, F correct.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04767767 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-c3bbe4b8f5e24016b2ea00501c262a89 |
| 出典メモ | uspto-grants-1988_08 |