Hexahydro-1H-azepine-1-ethanol → 2-Homopiperidinylethyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate

HRID 35547

反応式

HRID 35547 の反応式
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH:13][C:14]3[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=3[C:16]([O:18][CH3:19])=[O:17])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1.OC[CH2:28][N:29]1[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]1.[Na]>C1(C)C=CC=CC=1>[F:25][C:2]([F:1])([F:24])[C:3]1[CH:12]=[C:11]2[C:6]([C:7]([NH:13][C:14]3[CH:23]=[CH:22][CH:21]=[CH:20][C:15]=3[C:16]([O:18][CH2:19][CH2:28][N:29]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30]3)=[O:17])=[CH:8][CH:9]=[N:10]2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 88615Hexahydro-1H-azepine-1-ethanolHCID 5360545SodiumHCID 21294482Methyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate

生成物 1

HCID 571910892-Homopiperidinylethyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate収率 60%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

By treating 17.31 g of methyl 2-(7-trifluoromethyl-4-quinolyl)aminobenzoate (II, R=CF3, R"=CH3), 10.5 g of 1-(2-hydroxyethyl)homopiperidine in 130 ml of toluene and in the presence of sodium as described in Example 1, 20.6 g of a crude material are isolated. The recrystallization in diisopropyl ether enables to isolate 13.7 g (yield: 60%) of a whitish solid with m.p. 72°-75° C. and elemental analysis C, H, N, F correct.

後処理

  1. customare isolated
  2. customThe recrystallization in diisopropyl ether

出典と根拠

ORDレコード
ord-c3bbe4b8f5e24016b2ea00501c262a89
出典データセット
uspto-grants-1988_08
特許番号
US04767767

関連ノート

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