Cyanuric chloride → N,N',N"-(1,3,5-triazine-2,4,6-triyl)-tris-(1-amino-1-desoxy-D-glucitol)

HRID 355470

反応式

HRID 355470 の反応式
[N:1]1[C:8](Cl)=[N:7][C:5](Cl)=[N:4][C:2]=1Cl.[NH2:10][CH2:11][C@@H:12]([C@H:14]([C@@H:16]([C@@H:18]([CH2:20][OH:21])[OH:19])[OH:17])[OH:15])[OH:13].[C:22](=[O:25])([O-])[O-].[K+].[K+]>O>[N:1]1[C:8]([NH:10][CH2:11][C@@H:12]([C@H:14]([C@@H:16]([C@@H:18]([CH2:20][OH:21])[OH:19])[OH:17])[OH:15])[OH:13])=[N:7][C:5]([NH:10][CH2:11][C@@H:12]([C@H:14]([C@@H:16]([C@@H:18]([CH2:20][OH:21])[OH:19])[OH:17])[OH:15])[OH:13])=[N:4][C:2]=1[NH:10][CH2:11][C@@H:12]([C@H:14]([C@@H:16]([C@@H:18]([CH2:22][OH:25])[OH:19])[OH:17])[OH:15])[OH:13]

参加物

5

反応物 3

HCID 7954Cyanuric chlorideHCID 11430Potassium CarbonateHCID 452501Glucamine

生成物 1

HCID 54282659N,N',N"-(1,3,5-triazine-2,4,6-triyl)-tris-(1-amino-1-desoxy-D-glucitol)

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

184 mg of cyanuric chloride, 543.5 mg of D-glucamine and 450 mg of potassium carbonate were stirred at room temperature in 10 ml of water for three days. The thus-obtained crude product was thereupon chromatographed on LiChroprep RP-18 silica gel with water and subsequently with water containing an increasing amount of methanol. The relevant fractions were lyophilized; N,N',N"-(1,3,5-triazine-2,4,6-triyl)-tris-(1-amino-1-desoxy-D-glucitol) was thus obtained as a colorless powder, MS: m/z 619.2 ([M+H]+).

後処理

  1. customThe thus-obtained crude product
  2. customwas thereupon chromatographed on LiChroprep RP-18 silica gel with water and subsequently with water containing an increasing amount of methanol

出典と根拠

ORDレコード
ord-f347c46c7f684548ab38c55713a55352
出典データセット
uspto-grants-1998_11
特許番号
US05830920

関連ノート

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