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Tris(hydroxymethyl)aminomethane → N,N'-bis-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-L-tartaramide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tris(hydroxymethyl)aminomethane | HCID 6503 | — |
| 反応物 | Dimethyl L-tartrate | HCID 11851 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | N,N'-bis-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-L-tartaramide | HCID 54556382 | — |
反応手順
A suspension of 1.78 g of dimethyl L-tartrate and 4.85 g of tris-hydroxymethyl-methylamine in 50 ml of methanol was heated under reflux for 6 days and then concentrated. The residue was purified by chromatography over silica gel with ethyl acetate/methanol/water as the eluent and gave N,N'-bis-(2-hydroxy-1,1-bis-hydroxymethyl-ethyl)-L-tartaramide, [a]+101.00 (c 0.4; dimethyl sulfoxide), MS: m/z 357.3 ([M+H]+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05830920 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-26e82b218d7c4c3f984d97f4e457a6e5 |
| 出典メモ | uspto-grants-1998_11 |