2-(Bromomethoxy)ethyl acetate → 9-(2-acetoxyethoxy)methyl-7-benzyl-N2-acetylguaninium bromide

HRID 355534

反応式

HRID 355534 の反応式
N#N.[C:3]([NH:6][C:7]1[NH:8][C:9](=[O:23])[C:10]2[N:11]([CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:12]=[N:13][C:14]=2[N:15]=1)(=[O:5])[CH3:4].[C:24]([O:27][CH2:28][CH2:29][O:30][CH2:31][Br:32])(=[O:26])[CH3:25]>CN(C=O)C>[Br-:32].[C:24]([O:27][CH2:28][CH2:29][O:30][CH2:31][N:13]1[CH2:12][N:11]([CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[C:10]2[C:9](=[O:23])[NH2+:8][C:7]([NH:6][C:3](=[O:5])[CH3:4])=[N:15][C:14]1=2)(=[O:26])[CH3:25]

参加物

4

反応物 2

HCID 3676562-(Bromomethoxy)ethyl acetateHCID 136365317N2 acetyl-7-benzylguanine

生成物 1

HCID 701967829-(2-acetoxyethoxy)methyl-7-benzyl-N2-acetylguaninium bromide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

To a mixed solution containing 100 mg (0.35 mmol) of N2 -acetyl-7-benzylguanine and 1 ml of DMF was added 72 mg (0.37 mmol) of (2-acetoxyethoxy)methyl bromide [prepared by the method described in M. J. Robins et al., Can. J. Chem., 60, 547 (1982)]. The mixture was heated at 80° C. for 20 h, and then allowed to cool. The reaction solution was concentrated, and purified by silica-gel column chromatography to yield 9-(2-acetoxyethoxy)methyl-7-benzyl-N2 -acetylguaninium bromide.

後処理

  1. customprepared by the method
  2. temperatureto cool
  3. concentrationThe reaction solution was concentrated
  4. custompurified by silica-gel column chromatography

出典と根拠

ORDレコード
ord-fa01967fa69145cebfc99bd8dd6e4a83
出典データセット
uspto-grants-1998_11
特許番号
US05831092

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