化工社化工社 化学情報印刷レポート · 研究参考用
1-Chloro-4-(trifluoromethyl)benzene → 1-[4-(Trifluoromethyl)phenyl]piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Lithium Bromide | HCID 82050 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-[4-(Trifluoromethyl)phenyl]piperidine | HCID 425092 | — |
| 生成物 | 1-[3-(Trifluoromethyl)phenyl]piperidine | HCID 11770240 | — |
反応手順
In accordance with the GWI, 2.0 mmol of 4-chlorobenzotrifluoride, 2.4 mmol of piperidine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle ((trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium(II) in 10 ml of toluene are reacted. 4-Trifluoromethylphenylpiperidine and 3-trifluoromethylphenylpiperidine in the ratio 6:1 are obtained in 65% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05831128 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-a0215c4e20e2479e8ef59ab698c8bcbf |
| 出典メモ | uspto-grants-1998_11 |