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1-Chloro-4-(trifluoromethyl)benzene → 4-(4-Trifluoromethylphenyl)morpholine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| 反応物 | Morpholine | HCID 8083 | — |
| 反応物 | Lithium Bromide | HCID 82050 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4-(4-Trifluoromethylphenyl)morpholine | HCID 10933310 | — |
| 生成物 | 4-(3-(Trifluoromethyl)phenyl)morpholine | HCID 15420299 | — |
反応手順
2.0 mmol of 4-chlorobenzotrifluoride, 2.4 mmol of morpholine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium(II) in 10 ml of toluene are reacted according to the GWI to give 4-trifluoromethylphenylmorpholine and 3-trifluoromethylphenylmorpholine in the ratio 5:1 in 62% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05831128 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-2218640268a64655b55ace309eaf0f6d |
| 出典メモ | uspto-grants-1998_11 |