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1-Chloro-4-(trifluoromethyl)benzene → N,N-Dibutyl-3-(trifluoromethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Chloro-4-(trifluoromethyl)benzene | HCID 7394 | — |
| 反応物 | Dibutylamine | HCID 8148 | — |
| 反応物 | Lithium Bromide | HCID 82050 | — |
| 反応物 | Potassium tert-butoxide | HCID 23665647 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | N,N-Dibutyl-3-(trifluoromethyl)aniline | HCID 18943007 | — |
| 生成物 | N,N-Dibutyl-4-(trifluoromethyl)aniline | HCID 18943008 | — |
反応手順
2.0 mmol of 4-chlorobenzotrifluoride, 2.4 mmol of di-n-butylamine, 2.8 mmol of potassium tert-butoxide, 0.4 mmol of lithium bromide, 1.0 mol-% (9.4 mg) of palladacycle (trans-di(μ-aceto)-bis[o[di-o-tolylphosphino)benzyl]dipalladium (II) in 10 ml of toluene are reacted according to the GWI to give 4-trifluoromethylphenyl-di-n-butylamine and 3-trifluoromethylphenyl-di-n-butylamine in the ratio 7:1 in 58% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05831128 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-78047edeb39c43e8a9f0ce6ab17d7f15 |
| 出典メモ | uspto-grants-1998_11 |