Ammonia → (2S,3S)-2 ethyl-3-hydroxybutyramide

(2S,3S)-Ethyl 2 ethyl-3-hydroxybutyrate (1 gram) was dissolved in 5 ml of absolute ethanol, followed by the addition of 0.5 gram of gaseous ammonia. The solution was kept in a stoppered flask, and the progress of the reaction was followed by thin layer chromatography. After the reaction was judged complete, the ethanol was evaporated and the resulting residue redissolved in ethyl acetate. Ammonia was removed by extraction with 1% HCl, and the ethyl acetate solution was dried over MgSO4, filtered, and rotary evaporated to leave 0.7 grams of (2S,3S)-2 ethyl-3-hydroxybutyramide.

1. customThe solution was kept in a stoppered flask
2. customthe ethanol was evaporated
3. dissolutionthe resulting residue redissolved in ethyl acetate
4. customAmmonia was removed by extraction with 1% HCl
5. dry with materialthe ethyl acetate solution was dried over MgSO4
6. filtrationfiltered
7. customrotary evaporated

ORDレコード

ord-ff73b715d23c4b3ebd839108e5efb3e2

出典データセット

uspto-grants-1998_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US05834261