反応式
[C:1](OC(=O)C)(=[O:3])[CH3:2].[CH3:8][CH2:9][C@H:10]1[O:25][C:23](=[O:24])[C@H:22]([CH3:26])[C@@H:21]([O:27][C@@H:28]2[O:33][C@@H:32]([CH3:34])[C@H:31]([OH:35])[C@@:30]([O:37][CH3:38])([CH3:36])[CH2:29]2)[C@H:20]([CH3:39])[C@@H:19]([O:40][C@@H:41]2[O:46][C@H:45]([CH3:47])[CH2:44][C@H:43]([N:48]([CH3:50])[CH3:49])[C@H:42]2[OH:51])[C@@:18]([OH:53])([CH3:52])[CH2:17][C@@H:16]([CH3:54])[C:14](=[O:15])[C@H:13]([CH3:55])[C@@H:12]([OH:56])[C@@:11]1([OH:58])[CH3:57]>C(Cl)Cl>[CH3:8][CH2:9][C@H:10]1[O:25][C:23](=[O:24])[C@H:22]([CH3:26])[C@@H:21]([O:27][C@@H:28]2[O:33][C@@H:32]([CH3:34])[C@H:31]([OH:35])[C@@:30]([O:37][CH3:38])([CH3:36])[CH2:29]2)[C@H:20]([CH3:39])[C@@H:19]([O:40][C@@H:41]2[O:46][C@H:45]([CH3:47])[CH2:44][C@H:43]([N:48]([CH3:49])[CH3:50])[C@H:42]2[O:51][C:1]([CH3:2])=[O:3])[C@@:18]([OH:53])([CH3:52])[CH2:17][C@@H:16]([CH3:54])[C:14](=[O:15])[C@H:13]([CH3:55])[C@@H:12]([OH:56])[C@@:11]1([OH:58])[CH3:57]参加物
4
実験手順
Acetic anhydride (3.5 ml, 1.2 eq.) was added at ambient temperature to a solution of erythromycin A (23 g, commercially available from Abbott Laboratories) dissolved in 350 mL of methylene chloride. The reaction mixture was stirred for 12 hours at room temperature. The methylene chloride solution was washed twice with 100 mL of 1% sodium bicarbonate solution, once with 100 mL of water, dried over anhydrous sodium sulfate and filtered. Solvent was removed in vacuo to afford a white solid which was recrystallized from acetonitrile to the product in 71% yield.
後処理
- washThe methylene chloride solution was washed twice with 100 mL of 1% sodium bicarbonate solution, once with 100 mL of water
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- customSolvent was removed in vacuo
- customto afford a white solid which
- customwas recrystallized from acetonitrile to the product in 71% yield
出典と根拠
- ORDレコード
- ord-e24f9892a9344ca9bf340c33e656ffc1
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05834438
関連ノート
読み込み中…