HCID 13837186、化合物 → 3-(3-Ethyl-1,2,4-oxadiazol-5-yl)-9H-beta-carboline

HRID 355814ノート

反応式

HRID 355814 の反応式
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[C:3]([C:14](N2C=CN=C2)=O)[N:2]=1.[OH:21][NH:22][C:23](=[NH:26])[CH2:24][CH3:25]>C1(C)C=CC=CC=1.CN(C=O)C>[CH2:24]([C:23]1[N:26]=[C:14]([C:3]2[N:2]=[CH:1][C:13]3[NH:12][C:11]4[C:6]([C:5]=3[CH:4]=2)=[CH:7][CH:8]=[CH:9][CH:10]=4)[O:21][N:22]=1)[CH3:25]

参加物

5

反応物 2

HCID 13837186HCID 13837186、化合物HCID 178458070HCID 178458070、化合物

生成物 1

HCID 189407053-(3-Ethyl-1,2,4-oxadiazol-5-yl)-9H-beta-carboline収率 56.8%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 6228Dimethylformamide溶媒

実験手順

To a solution of Compound 1 (1.05 g, 4 mmol) in a mixture of toluene (50 mL) and DMF (50 mL), N-hydroxypropanimidamide (0.53 g, 6 mmol) was added. The resulting mixture was heated at 140°-150° C. for 7 h, and stirring continued for 3 days at room temperture. The solvents were removed in vacuo, and the oily residue precipitated from water. The white solid (1.0 g) was dried and submitted to column chromatography on silica gel with CH2Cl2 /methanol(9:1) as eluent. This afforded the title compound (0.6 g, 56%). M.p. 146°-149° C.

後処理

  1. additionwas added
  2. temperatureThe resulting mixture was heated at 140°-150° C. for 7 h
  3. customThe solvents were removed in vacuo
  4. customthe oily residue precipitated from water
  5. dry with materialThe white solid (1.0 g) was dried

出典と根拠

ORDレコード
ord-b526b37c7ff642cfaae9c95924f7015f
出典データセット
uspto-grants-1998_11
特許番号
US05834482

反応ノート

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