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Dimethylformamide → 4-(3-Dimethylaminophenoxy)butyronitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 3-(Dimethylamino)phenol | HCID 7421 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Bromobutyronitrile | HCID 21412 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(3-Dimethylaminophenoxy)butyronitrile | HCID 21294517 | — |
反応手順
A suspension of 3-dimethylaminophenol (5 g), potassium carbonate (10.05 g) and dimethylformamide (85 ml) was stirred at room temperature for 5 hours. 4-Bromobutyronitrile (7.3 ml) was added and the suspension stirred for 17 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and the solvent removed to yield 4-(3-dimethylaminophenoxy)butyronitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04767769 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-7c7eb924af47428b8286be45c1256f2f |
| 出典メモ | uspto-grants-1988_08 |