Dimethylformamide → 4-(3-Dimethylaminophenoxy)butyronitrile

HRID 35601

反応式

HRID 35601 の反応式
[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1.C(=O)([O-])[O-].[K+].[K+].CN(C)C=O.Br[CH2:23][CH2:24][CH2:25][C:26]#[N:27]>O>[CH3:1][N:2]([CH3:10])[C:3]1[CH:4]=[C:5]([CH:6]=[CH:7][CH:8]=1)[O:9][CH2:23][CH2:24][CH2:25][C:26]#[N:27]

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 74213-(Dimethylamino)phenolHCID 11430Potassium CarbonateHCID 214124-Bromobutyronitrile

生成物 1

HCID 212945174-(3-Dimethylaminophenoxy)butyronitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A suspension of 3-dimethylaminophenol (5 g), potassium carbonate (10.05 g) and dimethylformamide (85 ml) was stirred at room temperature for 5 hours. 4-Bromobutyronitrile (7.3 ml) was added and the suspension stirred for 17 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The extracts were washed with water, dried and the solvent removed to yield 4-(3-dimethylaminophenoxy)butyronitrile.

後処理

  1. stirringthe suspension stirred for 17 hours
  2. extractionextracted with ethyl acetate
  3. washThe extracts were washed with water
  4. customdried
  5. customthe solvent removed

出典と根拠

ORDレコード
ord-7c7eb924af47428b8286be45c1256f2f
出典データセット
uspto-grants-1988_08
特許番号
US04767769

関連ノート

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