Ethyl Acetate → HCID 10632473、化合物

HRID 356042ノート

反応式

HRID 356042 の反応式
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([CH3:13])=[CH:6][C:3]=1[CH:4]=[O:5].B(O[O-])=[O:15].[Na+].C(OCC)(=O)C>C(O)(=O)C>[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([CH3:13])=[CH:6][C:3]=1[C:4]([OH:15])=[O:5]

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 517072Sodium Perborate2 回HCID 10821873HCID 10821873、化合物

生成物 1

HCID 10632473HCID 10632473、化合物収率 77.1%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A solution of 2-chloro-5-methyl-4-nitrobenzaldehyde (1.72 g, 8.6 mmol) in acetic acid (20 ml) at 80° C. was treated with sodium perborate (2.64 g, 17.2 mmol). After 0.5 h a further portion of sodium perborate (1.32 g, 8.6 mmol) was added. After 0.25 h the reaction mixture was added to ethyl acetate--half saturated brine, and the organic extract dried (Na2SO4) and evaporated, affording the title product as a white solid (1.43 g, 77%).

後処理

  1. extractionhalf saturated brine, and the organic extract
  2. dry with materialdried (Na2SO4)
  3. customevaporated

出典と根拠

ORDレコード
ord-9c2c01ed0f344a57b267f2a70854d008
出典データセット
uspto-grants-1998_11
特許番号
US05834494

反応ノート

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