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Hydrochloric Acid → 5-Nitro-1-(3-pyridylcarbamoyl)indoline Hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Urea | HCID 1176 | — |
| 反応物 | 3-Pyridinecarbonyl Azide | HCID 19914 | — |
| 反応物 | 5-Nitroindoline | HCID 36219 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 5-Nitro-1-(3-pyridylcarbamoyl)indoline Hydrochloride | HCID 18940945 | 76% |
反応手順
This material was prepared from nicotinoyl azide (0.43 g, 2.9 mmol) and 5-nitroindoline (0.38 g, 2.3 mmol), and conversion of the precipitated urea to the salt using excess HCl in ether, following the procedure of Example 2. This gave the title compound (0.64 g, 76%) as a light yellow powder, m.p. 244°-7° C. (dec.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05834494 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-aafc92b2637a4682a1f40d81e42fab24 |
| 出典メモ | uspto-grants-1998_11 |