Water → 4-(3-Piperidinomethylphenylthio)butyronitrile

HRID 35605

反応式

HRID 35605 の反応式
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([SH:14])[CH:11]=[CH:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:22][CH2:23][CH2:24][C:25]#[N:26].O>CN(C)C=O>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([S:14][CH2:22][CH2:23][CH2:24][C:25]#[N:26])[CH:11]=[CH:12][CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 214124-BromobutyronitrileHCID 135055073-(Piperidin-1-ylmethyl)benzenethiol

生成物 1

HCID 212945544-(3-Piperidinomethylphenylthio)butyronitrile

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

A stirred suspension of 3-piperidinomethylthiophenol (0.36 g) in dry dimethylformamide (4 ml) was treated with anhydrous potassium carbonate (0.5 g) and stirred for 30 minutes. 4-Bromobutyronitrile (0.18 ml) was then added to the reaction mixture with dimethylformamide (1 ml) and the resultant suspension stirred at room temperature for 48 hours. The resulting product was poured into 5 volumes of water and extracted with ethyl acetate; the extracts were washed with water, dried and evaporated to give 4-(3-piperidinomethylphenylthio)butyronitrile as an orange-red oil.

後処理

  1. extractionextracted with ethyl acetate
  2. washthe extracts were washed with water
  3. customdried
  4. customevaporated

出典と根拠

ORDレコード
ord-f943add7633e41be847802063bf84698
出典データセット
uspto-grants-1988_08
特許番号
US04767769

関連ノート

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