3-Isocyanatopyridine → 6-Chloro-5-methylthio-1-(3-pyridylcarbamoyl)indoline

HRID 356057ノート

反応式

HRID 356057 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][NH:8]2)=[CH:4][C:3]=1[S:11][CH3:12].[N:13]1[CH:18]=[CH:17][CH:16]=[C:15]([N:19]=[C:20]=[O:21])[CH:14]=1>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][CH2:7][N:8]2[C:20](=[O:21])[NH:19][C:15]2[CH:14]=[N:13][CH:18]=[CH:17][CH:16]=2)=[CH:4][C:3]=1[S:11][CH3:12]

参加物

3

反応物 2

HCID 27604933-IsocyanatopyridineHCID 105599346-Chloro-5-methylthioindoline

生成物 1

HCID 106871306-Chloro-5-methylthio-1-(3-pyridylcarbamoyl)indoline収率 81%

実験手順

6-Chloro-5-methylthioindoline (D48) (0.70 g, 3.51 mmol) was treated with 3-pyridylisocyanate as in the procedure described in Example 1. The crude product was recrystallised from ethanol/diethyl ether to give the title compound (0.91 g, 81%) as a white crystalline solid m.p. 241°-242° C.

後処理

  1. customThe crude product was recrystallised from ethanol/diethyl ether

出典と根拠

ORDレコード
ord-3c738efee9224e08a9d50ad72d592fbf
出典データセット
uspto-grants-1998_11
特許番号
US05834494

反応ノート

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