化工社化工社 化学情報印刷レポート · 研究参考用
N-(Cyanomethyl)-phthalimide → 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(Cyanomethyl)-phthalimide | HCID 345881 | — |
| 反応物 | Diethyl dithiophosphate, potassium salt | HCID 1385274 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide | HCID 24696128 | — |
反応手順
In a 20 ml 4N solution of hydrogen chloride in ethyl acetate, 3.07 g of phthalimidoacetonitrile was dissolved. To the resulting solution, 3.17 ml of O,O-diethyl dithiophosphate was added, followed by stirring at room temperature for 6 hours. The precipitate formed was collected by filtration, and washed successively with ethyl acetate and diethyl ether, whereby 2.29 g of phthalimidothioacetamide was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05834499 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-447b185e459e4007afb89349afc2be54 |
| 出典メモ | uspto-grants-1998_11 |