2-Bromo-1-indanone → 2-phthalimidomethyl-8H-indeno[1,2-d]thiazole

HRID 356109

反応式

HRID 356109 の反応式
Br[CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=O.[C:12]1(=[O:26])[N:16]([CH2:17][C:18]([NH2:20])=[S:19])[C:15](=[O:21])[C:14]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:13]12>C(O)(C)C>[C:15]1(=[O:21])[N:16]([CH2:17][C:18]2[S:19][C:2]3[CH2:10][C:9]4[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=4[C:3]=3[N:20]=2)[C:12](=[O:26])[C:13]2=[CH:25][CH:24]=[CH:23][CH:22]=[C:14]12

参加物

4

反応物 2

HCID 1372032-Bromo-1-indanoneHCID 246961282-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethanethioamide

生成物 1

HCID 189409622-phthalimidomethyl-8H-indeno[1,2-d]thiazole収率 50.3%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

In 100 ml of isopropanol, 1.64 g of 2-bromo-1-indanone was dissolved. Then, 2.0 g of phthalimidothioacetamide was added, followed by heating under reflux for 6 hours. The precipitate thus formed was collected by filtration and then distributed between chloroform and a saturated aqueous solution of sodium bicarbonate. The organic layer was separated, washed successively with water and a saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate. The solvent was then evaporated, whereby 1.3 g of 2-phthalimidomethyl-8H-indeno[1,2-d]thiazole was obtained.

後処理

  1. temperatureby heating
  2. temperatureunder reflux for 6 hours
  3. customThe precipitate thus formed
  4. filtrationwas collected by filtration
  5. customThe organic layer was separated
  6. washwashed successively with water
  7. dry with materiala saturated aqueous solution of sodium chloride, and then dried over anhydrous sodium sulfate
  8. customThe solvent was then evaporated

出典と根拠

ORDレコード
ord-579db616259141bf9d77890262f0c176
出典データセット
uspto-grants-1998_11
特許番号
US05834499

関連ノート

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