Glycerol → Leukotriene B4

HRID 356126

反応式

HRID 356126 の反応式
C(OC(=O)CCC[CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH:12]=[CH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])C.C([O:25][C:26](=[O:46])[CH2:27][CH2:28]CCCC/C=C\CC=CCCCCCCCC)C.C([O:49]C(=O)CCC/C=C\CC=CC=CCCCCCCCCC)C.O[CH2:72][CH:73]([CH2:75]O)[OH:74]>>[CH3:21][CH2:20][CH2:19][CH2:18][CH2:17]/[CH:16]=[CH:15]\[CH2:14][C@@H:13]([OH:49])/[CH:12]=[CH:11]/[CH:10]=[CH:9]/[CH:8]=[CH:75]\[C@@H:73]([OH:74])[CH2:72][CH2:28][CH2:27][C:26]([OH:25])=[O:46]

参加物

5

反応物 4

HCID 753GlycerolHCID 880441548,11-cis-Eicosadienoic acid ethyl esterHCID 880442336,9-cis-Octadecadienoic acid ethyl esterHCID 883017505,8,10-cis-Eicosatrienoic acid ethyl ester

生成物 1

HCID 5280492Leukotriene B4

実験手順

10 g of 6,9-cis-octadecadienoic acid ethyl ester (95% purity) or 10 g of 8,11-cis-eicosadienoic acid ethyl ester (95% purity) or 10 g of 5,8,10-cis-eicosatrienoic acid ethyl ester (95% purity), and 1.2 g of yolk phospholipid were mixed, and 2.5% aqueous glycerol solution was added thereon to make the total weight 100 g, to prepare emulsion A, emulsion B or emulsion C, respectively. 3 ml of the emulsion A, B or C was injected to 5 rabbit (weighing 3.5 kg) through a tail vein, and before the injection (0 hour) and 6 hours from the injection, an amount of LTB4 produced by polymorphonuclear leukocyte (PMNL) was measured according to the same procedure as described in Example 1. The result is shown in Table 2.

後処理

  1. customto prepare emulsion A, emulsion B or emulsion C

出典と根拠

ORDレコード
ord-7f777dab99a546e19c3f92ac9d599683
出典データセット
uspto-grants-1998_11
特許番号
US05834512

関連ノート

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