Glycolic Acid → HCID 178519935、化合物
反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[C:10](O)(=O)[CH2:11][OH:12]>>[Cl:1][C:2]1[CH:3]=[C:4]2[N:9]=[C:10]([CH2:11][OH:12])[NH:8][C:5]2=[N:6][CH:7]=1参加物
3
実験手順
A procedure similar to that described in Preparation 43 was repeated, except that 7.67 g of 5-chloro-2,3-diaminopyridine (prepared as described in Preparation 62) and 18.6 g of glycolic acid were used, to give the title compound as a crude product. This crude product was purified by column chromatography through silica gel, using a 10:1 by volume mixture of ethyl acetate and methanol as the eluent, to give 8.83 g of the title compound, melting at 209°-211° C.
後処理
- customA procedure similar to that described in Preparation 43
出典と根拠
- ORDレコード
- ord-8d4ff0e2b0844f3d9d42f8523cfec11b
- 出典データセット
- uspto-grants-1998_11
- 特許番号
- US05834501
反応ノート
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