化工社化工社 化学情報印刷レポート · 研究参考用
N,N-diethyl-m-toluamide → N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-diethyl-m-toluamide | HCID 4284 | — |
| 反応物 | Chlorotrimethylsilane | HCID 6397 | — |
| 生成物 | N,N-Diethyl-5-methyl-2-(trimethylsilyl)benzamide | HCID 18630275 | 46% |
反応手順
These compounds were prepared from N,N-diethyl-3-methylbenzamide and 2.0 eq TMSCl according to General Method A. Purification by HPLC using 1:9 ethyl acetate/hexanes gave two products. Compound 63 was isolated as 6.0 g of a clear oil, a 46% yield. Compound 64 was isolated as 2.3 g of a clear oil, a 17% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05834447 |
| 出典データセット | uspto-grants-1998_11 |
| ORD ID | ord-ce55615b62654e459d205559d0d83700 |
| 出典メモ | uspto-grants-1998_11 |