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Tetradecyltrimethylammonium → 1-(1H-1,2,4-Triazol-1-yl)cyclopropyl 2,4-dichlorophenyl ketone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetradecyltrimethylammonium | HCID 14251 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sulfoxonium, trimethyl-, iodide (1:1) | HCID 74498 | — |
| 反応物 | 2',4'-Dichloro-2-(1H-1,2,4-triazol-1-yl)prop-2-enophenone | HCID 21294611 | — |
| 溶媒 | 1,1,1-Trichloroethane | HCID 6278 | — |
| 生成物 | 1-(1H-1,2,4-Triazol-1-yl)cyclopropyl 2,4-dichlorophenyl ketone | HCID 21294612 | — |
反応手順
2',4'-Dichloro-2-(1H-1,2,4-triazol-1-yl)prop-2-enophenone (0.27 g, 1.0 mMole) was added dropwise in 1,1,1-trichloroethane (2 ml) to a refluxing mixture of trimethylsulphoxonium iodide (0.33 g, 1.5 mMole), cetrimide (0.03 g), 1,1,1-trichloroethane (5 ml) and aqueous 2N sodium hydroxide (3 ml) with vigorous stirring over 2 minutes. After refluxing for a further 15 minutes the organic phase, after cooling was separated. Evaporation gave a gum, weight 0.11 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04767777 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-6c3a4db47a0a45f68dd1d01da747a525 |
| 出典メモ | uspto-grants-1988_08 |