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Hydrazinecarboxaldehyde → 5,6-Dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrazinecarboxaldehyde | HCID 12229 | — |
| 反応物 | 1,3,4,5-tetrahydro-2H-1,5-benzodiazepine-2-thione | HCID 4381402 | — |
| 溶媒 | 1-Butanol | HCID 263 | — |
| 生成物 | 5,6-Dihydro-4H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepine | HCID 21837004 | 37.3% |
反応手順
A mixture of 2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-2-thione (0.8 g) and 0.80 g of N-formylhydrazine in 8 ml of n-butanol is stirred and refluxed for 18 hours and the solvent removed under vacuum. Ice water is added to the residual solid and the mixture filtered to give 0.312 g of a gray solid, m.p. 162°-165° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05733905 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-b10c8b2565b240a1a2712a304e908573 |
| 出典メモ | uspto-grants-1998_03 |