関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Cysteamine Hydrochloride | HCID 9082 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| 反応物 | 2-Chlorothioxanthone | HCID 618848 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 2-(2-Aminoethylthio)thioxanthone | HCID 18939133 | — |
反応手順
17.0 g (0.15 mol) of cysteaminium chloride and 19.8 g (0.3 mol) of potassium hydroxide are boiled for 3 hours on a water separator in 180 ml of toluene. 24.6 g (0.1 mol) of 2-chlorothioxanthone and 180 mol of dimethylpropyl-eneurea are added to the evaporated residue, and the mixture is stirred for 20 hours at 100° C. The reaction mixture is poured into 1 l of 2N hydrochloric acid and the aqueous phase is extracted with ethyl acetate. The aqueous phase is then adjusted to pH 10 and extracted with ethyl acetate. Work-up of the organic phase gives 24.0 g of the analytically pure compound IIIb.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05837746 |
|---|
| 出典データセット | uspto-grants-1998_11 |
|---|
| ORD ID | ord-366630dcd511474087c4b01abebe1353 |
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| 出典メモ | uspto-grants-1998_11 |
|---|
