Methanol → Ibuprofen methyl ester

HRID 356841

反応式

HRID 356841 の反応式
[CH3:1][C@H:2]([C:13]([OH:15])=[O:14])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH:10]([CH3:12])[CH3:11])=[CH:5][CH:4]=1.S(=O)(=O)(O)O.[CH3:21]O>>[CH3:12][CH:10]([CH2:9][C:6]1[CH:7]=[CH:8][C:3]([CH:2]([C:13]([O:15][CH3:21])=[O:14])[CH3:1])=[CH:4][CH:5]=1)[CH3:11]

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 39912Dexibuprofen

生成物 1

HCID 109101Ibuprofen methyl ester

実験手順

S-(+)-ibuprofen (5.0 g; 0.024 mole) was shed into methanol (35 ml), concentrated sulfuric acid (1 ml) was added and the reaction mixture was heated for 3 hours at the reflux temperature of the reaction mixture. Then it was evaporated in vacuo at the temperature of 30° C. to dryness. S-(+)-ibuprofen methyl ester (5.1 g) was obtained.

後処理

  1. additionwas added
  2. temperaturethe reaction mixture was heated for 3 hours at the reflux temperature of the reaction mixture
  3. customThen it was evaporated in vacuo at the temperature of 30° C. to dryness

出典と根拠

ORDレコード
ord-df4c121a7edc488eacf23da102b372c5
出典データセット
uspto-grants-1998_11
特許番号
US05840714

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