Hydrochloric Acid → Methyl 12-aminododecanoate

HRID 356883

反応式

HRID 356883 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14].Cl.[CH3:17]O>>[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH3:17])=[O:14]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 6966112-Aminododecanoic Acid

生成物 1

HCID 3665980Methyl 12-aminododecanoate収率 98%

実験手順

To a suspension of 12-aminododecanoic acid (5.00 g, 23.3 mmol) in anhydrous MeOH (90 mL) was introduced hydrogen chloride gas for 25 minutes, during which time the suspension became clear. The solution was then stirred at room temperature for 3 hours and the solvent was removed in vacuo. The white solid residue was dissolved in H2O. Solid NaHCO3 was added to neutralize the solution to pH 8-9. The white precipitates thus formed were collected by vacuum filtration (5.20 g) (Yield: 98%).

後処理

  1. customthe solvent was removed in vacuo
  2. dissolutionThe white solid residue was dissolved in H2O
  3. additionSolid NaHCO3 was added
  4. customThe white precipitates thus
  5. customformed
  6. filtrationwere collected by vacuum filtration (5.20 g) (Yield: 98%)

出典と根拠

ORDレコード
ord-556f974df338495bab3fc6a50f4c8596
出典データセット
uspto-grants-1998_11
特許番号
US05840733

関連ノート

読み込み中…