Formamide → Hydrochloric Acid

HRID 35697ノート

反応式

HRID 35697 の反応式
C([NH:3][CH:4]([C:6]1([C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([Cl:17])[CH:11]=2)[CH2:9][CH2:8][CH2:7]1)[CH3:5])=O.C(N)=O>>[ClH:16].[Cl:17][C:12]1[CH:11]=[C:10]([C:6]2([CH:4]([NH2:3])[CH3:5])[CH2:9][CH2:8][CH2:7]2)[CH:15]=[CH:14][C:13]=1[Cl:16]

参加物

4

反応物 2

HCID 713FormamideHCID 23292610N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine

生成物 2

HCID 313Hydrochloric AcidHCID 130831401-[1-(3,4-Dichlorophenyl)cyclobutyl]ethylamine

実験手順

The preparation of N-formyl-1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine (m.p. 124°-125° C.) (Example 1(a) Formula I R1 =Me; R2 =H; R3 =H; R4 =CHO; R5 =4--Cl and R6 =3--Cl) described above was repeated and the product isolated by cooling the reaction mixture and collecting the solid produced by filtration. The formamide was then hydrolysed by concentrated hydrochloric acid in industrial methylated spirit to give the hydrochloride salt of 1-[1-(3,4-dichlorophenyl)cyclobutyl]ethylamine.

後処理

  1. customthe product isolated
  2. temperatureby cooling the reaction mixture
  3. customcollecting the solid
  4. customproduced by filtration

出典と根拠

ORDレコード
ord-484fc551f446422ab90c75b5447a20f6
出典データセット
uspto-grants-1988_08
特許番号
US04767790

反応ノート

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