Bromoacetone → 5-Chloro-2-methylimidazo[1,2-a]pyridine hydrobromide

HRID 357018

反応式

HRID 357018 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[N:3]=1.[Br:9][CH2:10][C:11](=O)[CH3:12]>C(O)C>[BrH:9].[Cl:8][C:4]1[N:3]2[CH:10]=[C:11]([CH3:12])[N:1]=[C:2]2[CH:7]=[CH:6][CH:5]=1

参加物

4

反応物 2

HCID 11715BromoacetoneHCID 2062462-Amino-6-chloropyridine

生成物 1

HCID 189367145-Chloro-2-methylimidazo[1,2-a]pyridine hydrobromide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 19.28 g (150 mmol) of 2-amino-6-chloropyridine in 150 ml of ethanol, 25 g (180 mmol) of bromoacetone was added at room temperature, followed by refluxing for 64 hours. After the reaction mixture was cooled, the solvent was distilled off. The residue was purified by recrystallization (solvent: ethanol-ethyl acetate) to yield 20.22 g (54.5%, light brown crystal) of the desired product.

後処理

  1. temperatureby refluxing for 64 hours
  2. temperatureAfter the reaction mixture was cooled
  3. distillationthe solvent was distilled off
  4. customThe residue was purified by recrystallization (solvent: ethanol-ethyl acetate)

出典と根拠

ORDレコード
ord-4df35b6cb8814ed7a93fd8fdc541f9cf
出典データセット
uspto-grants-1998_11
特許番号
US05840732

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