Hydrochloric Acid → HCID 178429829、化合物

HRID 357019ノート

反応式

HRID 357019 の反応式
Br.Cl[C:3]1[N:8]2[CH:9]=[C:10]([CH3:12])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1.Cl.[SH-:14].[Na+]>>[SH:14][C:3]1[N:8]2[CH:9]=[C:10]([CH3:12])[N:11]=[C:7]2[CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 28015Sodium hydrosulfideHCID 189367145-Chloro-2-methylimidazo[1,2-a]pyridine hydrobromide

生成物 1

HCID 178429829HCID 178429829、化合物

反応条件

温度
90 °C

実験手順

In a nitrogen atmosphere, 17.33 g (70 mmol) of 5-chloro-2-methylimidazo[1,2-a]pyridine hydrobromide was added to 70 ml of a sodium hydrosulfide solution at room temperature, followed by stirring at 90° C. for 24 hours. After the reaction mixture was cooled, concentrated hydrochloric acid was added until the reaction mixture's pH became 3-4. The resulting precipitate was collected by filtration, washed with water and dried to yield 12.32 g (quant, yellow powder) of the desired product.

後処理

  1. temperatureAfter the reaction mixture was cooled
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwashed with water
  4. customdried

出典と根拠

ORDレコード
ord-360c8d344a814fb89121864914482dc8
出典データセット
uspto-grants-1998_11
特許番号
US05840732

反応ノート

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