Hydrochloric Acid → 5-Propylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

HRID 357048ノート

反応式

HRID 357048 の反応式
[CH:1](=[C:4]1[S:8][C:7](=[O:9])[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][S:14][C:15]2[N:20]3[CH:21]=[CH:22][N:23]=[C:19]3[CH:18]=[CH:17][CH:16]=2)[C:5]1=[O:24])[CH2:2][CH3:3].[ClH:25]>CO>[ClH:25].[CH:1](=[C:4]1[S:8][C:7](=[O:9])[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][S:14][C:15]2[N:20]3[CH:21]=[CH:22][N:23]=[C:19]3[CH:18]=[CH:17][CH:16]=2)[C:5]1=[O:24])[CH2:2][CH3:3]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 572936285-Propylidene-3-(4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

生成物 1

HCID 867533435-Propylidene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 1.37 g (3.79 mmol) of 5-propylidene-3-(4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 50 ml of methanol, 0.35 ml of concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 1.66 g (100%, yellow oily substance) of the desired product.

後処理

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

出典と根拠

ORDレコード
ord-d7fbf8f54d604229b9caa460a7e9750e
出典データセット
uspto-grants-1998_11
特許番号
US05840732

反応ノート

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