Hydrochloric Acid → 5-(1-Methylpiperazin-4-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione trihydrochloride

HRID 357086

反応式

HRID 357086 の反応式
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH:8]=[C:9]2[S:13][C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][S:19][C:20]3[N:25]4[CH:26]=[CH:27][N:28]=[C:24]4[CH:23]=[CH:22][CH:21]=3)[C:10]2=[O:29])[CH2:4][CH2:3]1.[ClH:30]>CO>[ClH:30].[ClH:30].[ClH:30].[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH:8]=[C:9]2[S:13][C:12](=[O:14])[N:11]([CH2:15][CH2:16][CH2:17][CH2:18][S:19][C:20]3[N:25]4[CH:26]=[CH:27][N:28]=[C:24]4[CH:23]=[CH:22][CH:21]=3)[C:10]2=[O:29])[CH2:4][CH2:3]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 538972405-(1-Methylpiperazin-4-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione

生成物 1

HCID 867533455-(1-Methylpiperazin-4-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione trihydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 330 mg (0.76 mmol) of 5-(1-methylpiperazin-4-yl)methylene-3-[4-(imidazo[1,2-a]pyridin-5-ylthio)butyl]thiazolidine-2,4-dione in 10 ml of methanol, concentrated hydrochloric acid was added. After the solvent was distilled off, the residue was washed with diethyl ether to yield 360 mg (82.0%, white crystal) of the desired product.

後処理

  1. distillationAfter the solvent was distilled off
  2. washthe residue was washed with diethyl ether

出典と根拠

ORDレコード
ord-fdbd4583c0464cda93b74123defe05c3
出典データセット
uspto-grants-1998_11
特許番号
US05840732

関連ノート

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